How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review

被引：149
|
作者：
Freeman, Abigail M. [1 ]
Petrilli, Katherine [1 ]
Lees, Rachel [1 ,2 ]
Hindocha, Chandni [1 ,4 ]
Mokrysz, Claire [1 ]
Curran, H. Valerie [1 ]
Saunders, Rob [1 ]
Freeman, Tom P. [1 ,2 ,3 ]
机构：
[1] UCL, Clin Psychopharmacol Unit, Gower St, London WC1E 6BT, England
[2] Univ Bath, Addict & Mental Hlth Grp AIM, Bath BA2 7AY, Avon, England
[3] Kings Coll London, Natl Addict Ctr, London SE5 8BB, England
[4] UCL, Div Psychiat, Res Dept Mental Hlth Neurosci, Translat Psychiat Res Grp, Gower St, London WC1E 6BT, England
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2019年 / 107卷
关键词：
ACUTE ORAL DELTA(9)-TETRAHYDROCANNABINOL; PERSECUTORY IDEATION; DOUBLE-BLIND; CANNABINOIDS; MEMORY; RECEPTOR; TETRAHYDROCANNABINOL; EXPERIENCES; COGNITION; SYMPTOMS;
D O I：
10.1016/j.neubiorev.2019.09.036
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9-tetrahydrocannabinol (THC), but this has never been reviewed systematically. In this systematic review of how CBD influences the acute effects of THC we identified 16 studies involving 466 participants. Ten studies were judged at low risk of bias. The findings were mixed, although CBD was found to reduce the effects of THC in several studies. Some studies found that CBD reduced intense experiences of anxiety or psychosis-like effects of THC and blunted some of the impairments on emotion and reward processing. However, CBD did not consistently influence the effects of THC across all studies and outcomes. There was considerable heterogeneity in dose, route of administration and THC:CBD ratio across studies and no clear dose-response profile emerged. Although findings were mixed, this review suggests that CBD may interact with some acute effects of THC.
引用
收藏
页码：696 / 712
页数：17
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