Perceived Benefits and Risk of NSAIDs in Relation to Its Association with Cancer: A Comprehensive Review

被引：2

作者：

Kalita, Jishu ^{[1
]}

Dutta, Krishnanu ^{[1
]}

Sen, Saikat ^{[1
]}

Dey, Biplab Kumar ^{[1
]}

Gogoi, Pal ^{[1
]}

机构：

[1] Assam Down Town Univ, Fac Pharmaceut Sci, Gandhinagar 26, Guwahati, India

来源：

JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL | 2021年 / 33卷 / 40B期

关键词：

NSAID; cancer; COX-2; inhibitors; chronic inflammation-associated cancer; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ENDOMETRIAL CANCER; INDUCED APOPTOSIS; TUMOR-GROWTH; ASPIRIN; CELLS; PROSTAGLANDINS; INHIBITION; IBUPROFEN; RAT;

D O I：

10.9734/JPRI/2021/v33i40B32282

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Non-steroidal anti-inflammatory drugs (NSAIDs) are often used to treat fever and pain. Apart from its medicinal benefits, it is also well known for its numerous side effects, including myocardial infarction, gastrointestinal haemorrhage, renal failure, etc. Even beside these side effects NSAIDs are believed to play a major role in cancer. Though there are contrary of being inducing or preventive reason for cancer. Many studies shows NSAIDs are associated with the increasing risk of cancer. While as in various studies these drugs also have been investigated for their anti-cancer property as chronic inflammation has direct association with carcinogenesis. This review enlights the role of NSAIDs in cancer promotion and cancer prevention, connection between chronic inflammation and cancer, and some of the potentially lethal side effects of these drugs.

引用

页码：236 / 244

页数：9

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