This study aimed to investigate the effects of different sterilization methods on the flavor characteristics and volatile compounds of pomegranate (PG) juice. We analyzed three PG samples, namely conventional-pasteurized, high-temperature short-time-treated, and ultrasonic-sterilized (US) juice samples. Fresh-pressed PG (FJ) sample was used as the control. A total of 33 volatile compounds and six sensory attributes (floral, fruity, earthy/musty, sweet, green, and cooked flavor) of PG samples were analyzed by gas chromatography-mass spectrometry and quantitative descriptive sensory analysis. Results revealed differences in the samples' sensory profiles. Compared with thermal-sterilization methods, the low temperature and relatively mild sterilization conditions of US considerably preserved the amount of volatile compounds. Partial least-squares regression (PLSR) was performed to identify the relationships among sensory attributes, volatile compounds, and sterilization methods. Results showed that limonene, linalool, hexanal, and 6-methyl-5-hepten-2-one contributed greatly to the key aroma of FJ and US. Meanwhile, p-Cymene, (E)-2-nonenal, naphthalene, and benzothiazole were significantly correlated with the cooked flavor after thermal sterilization. PLSR further confirmed that compared with thermal-sterilization methods, US may be more beneficial in preserving the volatile compound amount and sensory profiles of PG juice.