Multiparametric Analysis of Intrinsically Disordered Proteins: Looking at Intrinsic Disorder through Compound Eyes

被引:66
|
作者
Uversky, Vladimir N. [1 ,2 ]
Dunker, A. Keith [3 ]
机构
[1] Univ S Florida, Coll Med, Dept Mol Med, Tampa, FL 33612 USA
[2] Russian Acad Sci, Inst Biol Instrumentat, Pushchino 142292, Moscow Region, Russia
[3] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA
基金
美国国家科学基金会;
关键词
C-TERMINAL DOMAIN; IONIZATION MASS-SPECTROMETRY; MEASLES-VIRUS NUCLEOPROTEIN; NATIVELY UNFOLDED PROTEINS; BACILLUS-PASTEURII UREG; MOLTEN GLOBULAR ENZYME; AMINO-ACID-COMPOSITION; UNSTRUCTURED PROTEINS; MOLECULAR RECOGNITION; FUNCTIONAL ANTHOLOGY;
D O I
10.1021/ac203096k
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Intrinsically disordered proteins are highly abundant in various proteomes. They are different from ordered proteins at many levels, and their structural and functional characterization requires special experimental and computational tools.
引用
收藏
页码:2096 / 2104
页数:9
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