Multiparametric Analysis of Intrinsically Disordered Proteins: Looking at Intrinsic Disorder through Compound Eyes

被引：66
作者：
Uversky, Vladimir N. [1 ,2 ]
Dunker, A. Keith [3 ]
机构：
[1] Univ S Florida, Coll Med, Dept Mol Med, Tampa, FL 33612 USA
[2] Russian Acad Sci, Inst Biol Instrumentat, Pushchino 142292, Moscow Region, Russia
[3] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA
来源：
ANALYTICAL CHEMISTRY | 2012年 / 84卷 / 05期
基金：
美国国家科学基金会;
关键词：
C-TERMINAL DOMAIN; IONIZATION MASS-SPECTROMETRY; MEASLES-VIRUS NUCLEOPROTEIN; NATIVELY UNFOLDED PROTEINS; BACILLUS-PASTEURII UREG; MOLTEN GLOBULAR ENZYME; AMINO-ACID-COMPOSITION; UNSTRUCTURED PROTEINS; MOLECULAR RECOGNITION; FUNCTIONAL ANTHOLOGY;
D O I：
10.1021/ac203096k
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Intrinsically disordered proteins are highly abundant in various proteomes. They are different from ordered proteins at many levels, and their structural and functional characterization requires special experimental and computational tools.
引用
收藏
页码：2096 / 2104
页数：9
相关论文
共 122 条
[1]  
ARNONE A, 1971, J BIOL CHEM, V246, P2302
[2]   Structural characterization of flexible proteins using small-angle X-ray scattering [J].
Bernado, Pau ;
Mylonas, Efstratios ;
Petoukhov, Maxim V. ;
Blackledge, Martin ;
Svergun, Dmitri I. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (17) :5656-5664
[3]   NMR observation of Tau in Xenopus oocytes [J].
Bodart, Jean-Francois ;
Wieruszeski, Jean-Michel ;
Amniai, Laziza ;
Leroy, Arnaud ;
Landrieu, Isabelle ;
Rousseau-Lescuyer, Arlette ;
Vilain, Jean-Pierre ;
Lippens, Guy .
JOURNAL OF MAGNETIC RESONANCE, 2008, 192 (02) :252-257
[4]   Predicting protein disorder and induced folding: From theoretical principles to practical applications [J].
Bourhis, Jean M. ;
Canard, Bruno ;
Longhi, Sonia .
CURRENT PROTEIN & PEPTIDE SCIENCE, 2007, 8 (02) :135-149
[5]   The C-terminal domain of measles virus nucleoprotein belongs to the class of intrinsically disordered proteins that fold upon binding to their physiological partner [J].
Bourhis, JM ;
Johansson, K ;
Receveur-Bréchot, V ;
Oldfield, CJ ;
Dunker, KA ;
Canard, B ;
Longhi, S .
VIRUS RESEARCH, 2004, 99 (02) :157-167
[6]   Combining prediction, computation and experiment for the characterization of protein disorder [J].
Bracken, C ;
Iakoucheva, LM ;
Rorner, PR ;
Dunker, AK .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2004, 14 (05) :570-576
[7]   The role of protein disorder in the 14-3-3 interaction network [J].
Bustos, Diego M. .
MOLECULAR BIOSYSTEMS, 2012, 8 (01) :178-184
[8]   Intrinsic disorder is a key characteristic in partners that bind 14-3-3 proteins [J].
Bustos, DM ;
Iglesias, AA .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2006, 63 (01) :35-42
[9]   Studies of the RNA degradosome-organizing domain of the Escherichia coli ribonuclease RNase E [J].
Callaghan, AJ ;
Aurikko, JP ;
IIag, LL ;
Grossmann, JG ;
Chandran, V ;
Kühnel, K ;
Poljak, L ;
Carpousis, AJ ;
Robinson, CV ;
Symmons, MF ;
Luisi, BF .
JOURNAL OF MOLECULAR BIOLOGY, 2004, 340 (05) :965-979
[10]   Abundance of intrinsic disorder in protein associated with cardiovascular disease [J].
Cheng, Yugong ;
LeGall, Tanguy ;
Oldfield, Christopher J. ;
Dunker, A. Keith ;
Uversky, Vladimir N. .
BIOCHEMISTRY, 2006, 45 (35) :10448-10460
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