Statins in Asthma: A Closer Look into the Pharmacological Mechanism of Action

被引：8

作者：

Al-Sawalha, Nour A. ^{[1
]}

Knoll, Brian J. ^{[2
]}

机构：

[1] Jordan Univ Sci & Technol, Coll Pharm, Irbid 22110, Jordan

[2] Univ Houston, Coll Pharm, Houston, TX 77030 USA

来源：

PHARMACOLOGY | 2016年 / 98卷 / 5-6期

关键词：

Asthma; Statins; 3-Hydroxy-3-methyl-glutaryl-CoA reductase inhibitors; Isoprenylation; Animal model of asthma; Subepithelial fibrosis; Eosinophils; AIRWAY SMOOTH-MUSCLE; OBSTRUCTIVE PULMONARY-DISEASE; GOBLET CELL HYPERPLASIA; RHO-ASSOCIATED KINASE; FACTOR-KAPPA-B; ALLERGIC-ASTHMA; MURINE MODEL; INHALED CORTICOSTEROIDS; ANTIGEN PRESENTATION; MUCUS SECRETION;

D O I：

10.1159/000449062

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of stains in asthma is mediated through targeting several signaling molecules that are involved in the development of asthma phenotype. In vitro and in vivo studies revealed that statins reduce airway smooth muscle cells proliferation and inflammatory mediators' release. Statins reduce chemokine release and mucus production from airway epithelial cells besides attenuating subepithelial fibrosis and eosinophils recruitment. In acute and chronic allergen driven animal models of asthma, statins reduce airway hyper-responsiveness, inflammation and remodeling. However, the effectiveness of statins in clinical trials results in contradictory conclusions based on study design and treatment protocol. Therefore, more clinical trials are needed to evaluate their role in asthma patients. (C) 2016 S. Karger AG, Basel

引用

页码：279 / 283

页数：5

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