Applications of chiral allenylzinc additions and Noyori asymmetric reductions to an enantioselective synthesis of a C3-C13 precursor of the polyketide phosphatase inhibitor cytostatin

被引：26

作者：

Marshall, JA ^{[1
]}

Ellis, K ^{[1
]}

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 07期

关键词：

allenylzinc; asymmetric reduction; polyketide; hydrogenation;

D O I：

10.1016/j.tetlet.2003.12.067

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 12-step synthesis of a C3-C13 precursor of the protein phosphatase inhibitor cytostatin is described. Key stereocenters were introduced by a chiral allenylzinc addition and Noyori asymmetric-transfer hydrogenation. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1351 / 1353

页数：3

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