Nuclear reaction measurements of 95 MeV/u 12C interactions on PMMA for hadrontherapy

被引：28

作者：

Braunn, B. ^{[1
]}

Labalme, M. ^{[1
]}

Ban, G. ^{[1
]}

Chevallier, M. ^{[3
]}

Colin, J. ^{[1
]}

Cussol, D. ^{[1
]}

Dauvergne, D. ^{[3
]}

Fontbonne, J. M. ^{[1
]}

Haas, F. ^{[2
]}

Guertin, A. ^{[5
,6
]}

Lebhertz, D. ^{[2
]}

Le Foulher, F. ^{[3
]}

Pautard, C. ^{[1
]}

Ray, C. ^{[3
]}

Rousseau, M. ^{[2
]}

Salsac, M. D. ^{[4
]}

Stuttge, L. ^{[2
]}

Testa, E. ^{[3
]}

Testa, M. ^{[3
]}

机构：

[1] Univ Caen, LPC Caen, ENSICAEN, CNRS IN2P3, F-14032 Caen, France

[2] IPHC Strasbourg, Strasbourg, France

[3] IPN Lyon, Lyon, France

[4] CEA IRFU SPhN Saclay, Gif Sur Yvette, France

[5] Ecole Mines, SUBATECH, CNRS IN2P3, Nantes, France

[6] Univ Nantes, Nantes, France

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 2011年 / 269卷 / 22期

关键词：

Hadrontherapy; C-12; fragmentation; FRAGMENTATION; NEUTRONS; MEDIA; BEAM;

D O I：

10.1016/j.nimb.2011.08.010

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The ion dose deposition in tissues is characterized by a favorable depth dose profile (i.e. Bragg peak) and a small lateral spread. In order to keep these benefits of ions in cancer treatments, a very high accuracy is required on the dose deposition ( +/- 3%). For given target stoichiometry and geometry, the largest uncertainty on the physical dose deposition is due to the ion nuclear fragmentation. We have performed an experiment at GANIL with a 95 MeV/u C-12 beam on thick tissue equivalent PMMA targets (thicknesses: 5, 10, 15,20 and 25 mm). The main goals of this experiment are to provide experimental fragmentation data for benchmarking the physical models used for treatment planning. Production rates, energy and angular distributions of charged fragments have been measured. The purpose of this paper is to present the results of this experiment. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：2676 / 2684

页数：9

共 21 条

[1] GEANT4-a simulation toolkit [J].

Agostinelli, S ;

Allison, J ;

Amako, K ;

Apostolakis, J ;

Araujo, H ;

Arce, P ;

Asai, M ;

Axen, D ;

Banerjee, S ;

Barrand, G ;

Behner, F ;

Bellagamba, L ;

Boudreau, J ;

Broglia, L ;

Brunengo, A ;

Burkhardt, H ;

Chauvie, S ;

Chuma, J ;

Chytracek, R ;

Cooperman, G ;

Cosmo, G ;

Degtyarenko, P ;

Dell'Acqua, A ;

Depaola, G ;

Dietrich, D ;

Enami, R ;

Feliciello, A ;

Ferguson, C ;

Fesefeldt, H ;

Folger, G ;

Foppiano, F ;

Forti, A ;

Garelli, S ;

Giani, S ;

Giannitrapani, R ;

Gibin, D ;

Cadenas, JJG ;

González, I ;

Abril, GG ;

Greeniaus, G ;

Greiner, W ;

Grichine, V ;

Grossheim, A ;

Guatelli, S ;

Gumplinger, P ;

Hamatsu, R ;

Hashimoto, K ;

Hasui, H ;

Heikkinen, A ;

Howard, A .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2003, 506 (03) :250-303

[2] Fragmentation of 95 MeV/u 12C and 75 MeV/u 13C.: Application to secondary-beam production [J].

Farès, G ;

Bimbot, R ;

Hachem, S ;

Mirea, M ;

Anne, R ;

Benfoughal, T ;

Cabot, C ;

Clapier, F ;

Delbourgo-Salvador, P ;

Ethvignot, T ;

Lefebvre, A ;

Lewitowicz, M ;

Roussel-Chomaz, P ;

Saint-Laurent, MG ;

Sauvestre, JE ;

Sida, JL ;

Feng, YY .

EUROPEAN PHYSICAL JOURNAL A, 2004, 19 (01) :105-116

[3]

Golovkov M, 1997, INT CONGR SER, V1144, P316

[4] Ion beam transport in tissue-like media using the Monte Carlo code SHIELD-HIT [J].

Gudowska, I ;

Sobolevsky, N ;

Andreo, P ;

Belkic, D ;

Brahme, A .

PHYSICS IN MEDICINE AND BIOLOGY, 2004, 49 (10) :1933-1958

[5] Fast neutrons produced by nuclear fragmentation in treatment irradiations with 12C beam [J].

Gunzert-Marx, K ;

Schardt, D ;

Simon, RS .

RADIATION PROTECTION DOSIMETRY, 2004, 110 (1-4) :595-600

[6] Secondary beam fragments produced by 200 MeVu-1 12C ions in water and their dose contributions in carbon ion radiotherapy [J].

Gunzert-Marx, K. ;

Iwase, H. ;

Schardt, D. ;

Simon, R. S. .

NEW JOURNAL OF PHYSICS, 2008, 10

[7] Experimental fragmentation studies with 12C therapy beams [J].

Haettner, E. ;

Iwase, H. ;

Schardt, D. .

RADIATION PROTECTION DOSIMETRY, 2006, 122 (1-4) :485-487

[8]

Haettner E., 2006, THESIS KUNGLIGA TEKN

[9]

Ikeda K., 1968, Progress of Theoretical Physics Supplement, P464, DOI 10.1143/PTPS.E68.464

[10]

Jakel O, 1998, PHYS MEDICA, V14, P53

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