TCR-T Immunotherapy: The Challenges and Solutions

被引：69

作者：

Liu, Yating ^{[1
,2
]}

Yan, Xin ^{[2
]}

Zhang, Fan ^{[2
]}

Zhang, Xiaoxia ^{[2
]}

Tang, Futian ^{[2
]}

Han, Zhijian ^{[2
]}

Li, Yumin ^{[2
]}

机构：

[1] Lanzhou Univ, Dept Oncol, Hosp 2, Lanzhou, Peoples R China

[2] Lanzhou Univ, Key Lab Digest Syst Tumors Gansu Prov, Hosp 2, Lanzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 11卷

关键词：

receptor-engineered T cell; immunotherapy; challenges; solutions; solid tumors; UMBILICAL-CORD BLOOD; ADOPTIVE CELL TRANSFER; IMMUNE MODULATION; CANCER REGRESSION; REGENERATIVE THERAPY; METASTATIC MELANOMA; GENE-TRANSFER; MOUSE MODELS; CD4+T CELLS; ALPHA-BETA;

D O I：

10.3389/fonc.2021.794183

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

T cell receptor-engineered T cell (TCR-T) therapy is free from the limit of surface antigen expression of the target cells, which is a potential cellular immunotherapy for cancer treatment. Significant advances in the treatment of hematologic malignancies with cellular immunotherapy have aroused the interest of researchers in the treatment of solid tumors. Nevertheless, the overall efficacy of TCR-T cell immunotherapy in solid tumors was not significantly high when compared with hematological malignancies. In this article, we pay attention to the barriers of TCR-T cell immunotherapy for solid tumors, as well as the strategies affecting the efficacy of TCR-T cell immunotherapy. To provide some reference for researchers to better overcome the impact of TCR-T cell efficiency in solid tumors.

引用

页数：14

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