Synthesis of 4'-C-acylated thymidines

被引：62

作者：

Marx, A ^{[1
]}

Erdmann, P ^{[1
]}

Senn, M ^{[1
]}

Korner, S ^{[1
]}

Jungo, T ^{[1
]}

Petretta, M ^{[1
]}

Imwinkelried, P ^{[1
]}

Dussy, A ^{[1
]}

Kulicke, KJ ^{[1
]}

Macko, L ^{[1
]}

Zehnder, M ^{[1
]}

Giese, B ^{[1
]}

机构：

[1] UNIV BASEL,DEPT CHEM,CH-4056 BASEL,SWITZERLAND

来源：

HELVETICA CHIMICA ACTA | 1996年 / 79卷 / 07期

关键词：

D O I：

10.1002/hlca.19960790720

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two synthetic pathways towards 4'-C-acylthymidines are presented. These modified mononucleosides are precursors of the 2'-deoxyribonucleotide 4'-C-radical. They were converted into their corresponding 3'-O-[(2-cyanoethyl) N,N-diisopropylphosphoramidites] 3a-c and incorporated in oligonucleotides by solid-phase synthesis. The structure of some modified nucleosides was revealed by X-ray crystal-structure analysis.

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页码：1980 / 1994

页数：15

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