Osteoclast biology in the single-cell era

被引：25

作者：

Tsukasaki, Masayuki ^{[1
]}

Takayanagi, Hiroshi ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med & Fac Med, Dept Immunol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

来源：

INFLAMMATION AND REGENERATION | 2022年 / 42卷 / 01期

基金：

日本学术振兴会;

关键词：

Osteoclast; Single-cell analysis; Osteoblast; Bone metabolism; Osteoimmunology; CD4(+) T-CELLS; INHIBITORY FACTOR; DENDRITIC CELLS; DC-STAMP; BONE; OSTEOPROTEGERIN; FUSION; LIGAND; DIFFERENTIATION; IDENTIFICATION;

D O I：

10.1186/s41232-022-00213-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Osteoclasts, the only cells that can resorb bone, play a central role in bone homeostasis as well as bone damage under pathological conditions such as osteoporosis, arthritis, periodontitis, and bone metastasis. Recent studies using single-cell technologies have uncovered the regulatory mechanisms underlying osteoclastogenesis at unprecedented resolution and shed light on the possibility that there is heterogeneity in the origin, function, and fate of osteoclast-lineage cells. Here, we discuss the current advances and emerging concepts in osteoclast biology.

引用

页数：9

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