The lysosome turns fifty

被引：309
作者：
de Duve, C [1 ]
机构：
[1] Catholic Univ Louvain, B-3000 Louvain, Belgium
[2] Rockefeller Univ, New York, NY 10021 USA
来源：
NATURE CELL BIOLOGY | 2005年 / 7卷 / 09期
关键词：
D O I：
10.1038/ncb0905-847
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the course of an investigation aimed at characterizing hepatic glucose 6- phosphatase, the unrelated acid phosphatase of rat liver was serendipitously observed to be latent and particle- bound in freshly prepared homogenates. Experiments designed to elucidate this intriguing finding led, 50 years ago, to the discovery of lysosomes. This could not have happened if strict adherence to a previously set programme had been mandatory.
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页码：847 / 849
页数：3
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