Reductive amination with zinc powder in aqueous media

被引：20

作者：

Giovenzana, Giovanni B. ^{[1
]}

Imperio, Daniela ^{[1
]}

Penoni, Andrea ^{[2
]}

Palmisano, Giovanni ^{[2
]}

机构：

[1] Univ Piemonte Orientale, DiSCAFF, I-28100 Novara, Italy

[2] Univ Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 7卷

关键词：

aldehydes; amines; reductive amination; water; zinc; TRANSFER HYDROGENATION; CONVENIENT METHOD; ALDEHYDES; KETONES; IMINES; AMINES; WATER; EFFICIENT; BORANE;

D O I：

10.3762/bjoc.7.125

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydrides in chlorinated or highly flammable solvents.

引用

页码：1095 / 1099

页数：5

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