Gadolinium Deposition in the Brain: Current Updates

被引：98
作者：
Choi, Jin Woo [1 ]
Moon, Won-Jin [1 ]
机构：
[1] Konkuk Univ, Med Ctr, Sch Med, Dept Radiol, 120-1 Neungdong Ro, Seoul 05030, South Korea
来源：
KOREAN JOURNAL OF RADIOLOGY | 2019年 / 20卷 / 01期
关键词：
Pharmacovigilance and Risk Assessment Committee; Ministry of Food and Drug Safety in Korea; Deposition mechanism; Thermodynamic stability; Chelating ligand; Gadoilnium; Brain deposition; T1-WEIGHTED MR-IMAGES; NEPHROGENIC SYSTEMIC FIBROSIS; HIGH-SIGNAL INTENSITY; HYPERINTENSE DENTATE NUCLEUS; DEEP CEREBELLAR NUCLEI; CONTRAST AGENTS; MAGNETIC-RESONANCE; GLOBUS-PALLIDUS; MULTIPLE ADMINISTRATIONS; GADOPENTETATE DIMEGLUMINE;
D O I：
10.3348/kjr.2018.0356
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Gadolinium-based contrast agents (GBCAs) are commonly used for enhancement in MR imaging and have long been considered safe when administered at recommended doses. However, since the report that nephrogenic systemic fibrosis is linked to the use of GBCAs in subjects with severe renal diseases, accumulating evidence has suggested that GBCAs are not cleared entirely from our bodies; some GBCAs are deposited in our tissues, including the brain. GBCA deposition in the brain is mostly linked to the specific chelate structure of the GBCA: linear GBCAs were responsible for brain deposition in almost all reported studies. This review aimed to summarize the current knowledge about GBCA brain deposition and discuss its clinical implications.
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页码：134 / 147
页数：14
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