Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage

被引：77

作者：

Huang, Huirong ^{[1
]}

Lou, Zijian ^{[1
,2
]}

Zheng, Shimin ^{[1
]}

Wu, Jianing ^{[1
]}

Yao, Qing ^{[3
]}

Chen, Ruijie ^{[1
]}

Kou, Longfa ^{[1
]}

Chen, Daosen ^{[2
]}

机构：

[1] Wenzhou Med Univ, Dept Pharm, Wenzhou Municipal Key Lab Pediat Pharm, Affiliated Hosp & Yuying Childrens Hosp 2, 109 Xueyuan West Rd, Wenzhou 325027, Peoples R China

[2] Wenzhou Med Univ, Dept Orthoped, Affiliated Hosp & Yuying Childrens Hosp 2, 109 Xueyuan West Rd, Wenzhou 325027, Peoples R China

[3] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China

来源：

DRUG DELIVERY | 2022年 / 29卷 / 01期

关键词：

Drug delivery system; osteoarthritis; sustained-release; permeability; intra-articular; MESENCHYMAL STEM-CELLS; HYALURONIC-ACID; ARTICULAR-CARTILAGE; KNEE OSTEOARTHRITIS; IN-VIVO; CHONDROGENIC DIFFERENTIATION; PLGA MICROSPHERES; PROTEIN CORONA; NANOPARTICLES; RETENTION;

D O I：

10.1080/10717544.2022.2048130

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Osteoarthritis (OA) is a progressive chronic inflammation that leads to cartilage degeneration. OA Patients are commonly given pharmacological treatment, but the available treatments are not sufficiently effective. The development of sustained-release drug delivery systems (DDSs) for OA may be an attractive strategy to prevent rapid drug clearance and improve the half-life of a drug at the joint cavity. Such delivery systems will improve the therapeutic effects of anti-inflammatory effects in the joint cavity. Whereas, for disease-modifying OA drugs (DMOADs) which target chondrocytes or act on mesenchymal stem cells (MSCs), the cartilage-permeable DDSs are required to maximize their efficacy. This review provides an overview of joint structure in healthy and pathological conditions, introduces the advances of the sustained-release DDSs and the permeable DDSs, and discusses the rational design of the permeable DDSs for OA treatment. We hope that the ideas generated in this review will promote the development of effective OA drugs in the future.

引用

页码：767 / 791

页数：25

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