A Novel ALK-THBS1 Fusion in a Laryngeal Inflammatory Myofibroblastic Tumour: A Case Report and Literature Review

被引：7

作者：

Elktaibi, Abderrahim ^{[1
]}

Benzerdjeb, Nazim ^{[2
]}

Ameur, Fatima ^{[3
]}

Daveau, Clementine ^{[4
]}

Tantot, Juliet ^{[2
]}

Martineau, Valerie Costes ^{[1
]}

机构：

[1] CHU Montpellier, Dept Pathol, Montpellier, France

[2] CHU Lyon, Dept Pathol, Lyon, France

[3] CHU Lyon, Dept Radiol, Lyon, France

[4] CHU Lyon, Dept Surg, Lyon, France

来源：

HEAD & NECK PATHOLOGY | 2020年 / 14卷 / 02期

关键词：

Inflammatory myofibroblastic tumor; Laryngeal tumor; Anaplastic lymphoma kinase; Immunohistochemistry; ALK-THBS1; fusion; ALK; PSEUDOTUMOR;

D O I：

10.1007/s12105-019-01061-x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Inflammatory myofibroblastic tumor (IMT) is an uncommon neoplasm most frequently seen in the abdomino-pelvic region and lungs of children and young adults. Laryngeal tumors are rare. We present a case of a 23-year-old patient with a 5 month history of laryngitis and aphonia unresolved by corticotherapy. Laryngoscopy revealed a small, non-ulcerated, subepithelial, polypoid mass arising from the right vocal cord. The diagnosis of IMT with ALK expression was supported by histopathologic and molecular analysis. The THBS1 fusion partner was identified by RNA-sequencing analysis for the first time in a laryngeal IMT. This fusion partner has only been identified in six uterine IMTs thus far. Conservative excision of the lesion yielded excellent functional results for the patient. The voice was preserved and no recurrences were seen after 6 months of follow-up.

引用

页码：454 / 458

页数：5

共 29 条

[1]

Alhumaid H, 2011, INT J HEALTH SCI-IJH, V5, P187

[2] Molecular Characterization of Inflammatory Myofibroblastic Tumors With Frequent ALK and ROS1 Gene Fusions and Rare Novel RET Rearrangement [J].

Antonescu, Cristina R. ;

Suurmeijer, Albert J. H. ;

Zhang, Lei ;

Sung, Yun-Shao ;

Jungbluth, Achim A. ;

Travis, William D. ;

Al-Ahmadie, Hikmat ;

Fletcher, Christopher D. M. ;

Alaggio, Rita .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2015, 39 (07) :957-967

[3] Inflammatory myofibroblastic tumor of the larynx with anaplastic lymphoma kinase (ALK) protein overexpression. A case report [J].

Bellezza, Guido ;

Cavaliere, Antonio ;

Del Sordo, Rachele ;

Sidoni, Angelo .

TUMORI, 2006, 92 (05) :449-451

[4] Inflammatory myofibroblastic tumor of the uterus: a clinicopathological, immunohistochemical, and molecular analysis of 13 cases highlighting their broad morphologic spectrum [J].

Bennett, Jennifer A. ;

Nardi, Valentina ;

Rouzbahman, Marjan ;

Morales-Oyarvide, Vicente ;

Nielsen, G. Petur ;

Oliva, Esther .

MODERN PATHOLOGY, 2017, 30 (10) :1489-1503

[5] ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor [J].

Coffin, CM ;

Patel, A ;

Perkins, S ;

Elenitoba-Johnson, KSJ ;

Perlman, E ;

Griffin, CA .

MODERN PATHOLOGY, 2001, 14 (06) :569-576

[6] EXTRAPULMONARY INFLAMMATORY MYOFIBROBLASTIC TUMOR (INFLAMMATORY PSEUDOTUMOR) - A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF 84 CASES [J].

COFFIN, CM ;

WATTERSON, J ;

PRIEST, JR ;

DEHNER, LP .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1995, 19 (08) :859-872

[7]

Coffin CM., 2013, World Health Organization Classification of Tumours of Soft Tissue and Bone, V4th ed, P83

[8] Recurrent inflammatory myofibroblastic tumor of the glottis mimicking malignancy [J].

Corsi, A ;

Ciofalo, A ;

Leonardi, M ;

Zambetti, G ;

Bosman, C .

AMERICAN JOURNAL OF OTOLARYNGOLOGY, 1997, 18 (02) :121-126

[9] An inflammatory pseudotumour of the larynx: a case report and literature review of an unusual tumour [J].

Dava, Chaido J. ;

Hajiioannou, Jiannis K. ;

Terzis, Anastasios ;

Bizakis, John .

ECANCERMEDICALSCIENCE, 2012, 6

[10] Inflammatory Myofibroblastic Tumor of the Larynx-A Case Report [J].

Do, Bao Anh ;

Varshney, Rickul ;

Zawawi, Faisal ;

Levental, Mark ;

Caglar, Derin ;

Young, Jonathan .

JOURNAL OF VOICE, 2014, 28 (02) :258-261

← 1 2 3 →