The expression pattern of tomoregulin-1 in urodele limb regeneration and mouse limb development

被引：10
作者：
da Silva, SM
Gates, PB
Eib, DW
Martens, GJM
Brockes, JP
机构：
[1] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
[2] Univ Nijmegen, Dept Anim Physiol NCMLS 275 RT, NL-6525 GA Nijmegen, Netherlands
来源：
MECHANISMS OF DEVELOPMENT | 2001年 / 104卷 / 1-2期
基金：
英国医学研究理事会;
关键词：
newt; blastema; follistatin; EGF; retinoic acid; tomoregulin-1;
D O I：
10.1016/S0925-4773(01)00362-8
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Tomoregulin-1 (TMEFF1) was first identified as a gene implicated in pituitary secretion in Xenopus laevis. The predicted structure of TMEFF1 is that of a transmembrane protein with a highly conserved cytoplasmic tail, two follistatin domains and one modified EGF domain in its extracellular region. We report the cloning of the newt orthologue, and show that the expression of TMEFF1 is upregulated in the blastema during limb regeneration, and is also expressed in mouse embryonic limb development. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：125 / 128
页数：4
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