Impact of CYP2C9, VKORC1, ApoE and ABCB1 polymorphisms on stable warfarin dose requirements in elderly Chinese patients

被引：14

作者：

Li, Wenyan ^{[1
]}

Zhao, Ping ^{[2
]}

Chen, Liwen ^{[1
]}

Lai, Xiaoyin ^{[3
]}

Shi, Guohua ^{[1
]}

Li, Longxuan ^{[3
]}

Dong, Jing ^{[1
]}

机构：

[1] Second Mil Med Univ, Gongli Hosp Pudong New Area, Dept Pharm, 219 Miaopu Rd, Shanghai 200135, Peoples R China

[2] Lanshi Hosp, Dept Endocrinol, Lanzhou 730000, Peoples R China

[3] Second Mil Med Univ, Gongli Hosp Pudong New Area, Dept Neurol, 219 Miaopu Rd, Shanghai 200135, Peoples R China

来源：

PHARMACOGENOMICS | 2020年 / 21卷 / 02期

关键词：

ABCB1; ApoE; CYP2C9; VKORC1; gene polymorphism; stable warfarin dose; APOLIPOPROTEIN-E GENOTYPE; COMPARATIVE PERFORMANCE; GENETIC POLYMORPHISMS; AMERICAN-COLLEGE; ASSOCIATION; THERAPY; ALGORITHMS; HAPLOTYPES; RESISTANCE; ALLELE;

D O I：

10.2217/pgs-2019-0139

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: To analyze the impact of nongenetic factors and gene polymorphisms on warfarin dose requirements in elderly Shanghai Han Chinese patients. Materials & methods: Genotypes of CYP2C9 (rs1799853 and rs1057910), FPGS (rs7856096), ApoE (rs7412 and rs429358), GGCX (rs699664 and rs12714145), EPHX1 (rs4653436, rs1877724, rs1051740 and rs1131873), NQO1 (rs1800566 and rs10517), ABCB1 (rs1045642), VKORC1 (rs9923231) and CYP4F2 (rs2108622) in 214 patients with stable warfarin dose were determined and their demographic characteristics were recorded. Results: Multiple linear regression analysis revealed that VKORC1 rs9923231, CYP2C9*3 rs1057910, ApoE rs7412, age, BMI and concomitant amiodarone could explain 37.0% of the individual variations of daily stable warfarin dose. Conclusion:VKORC1 rs9923231, CYP2C9*3 rs1057910, ApoE rs7412, age, BMI and concomitant amiodarone play an important role in stable dose variation of warfarin in elderly Shanghai Han Chinese patients, whereas ABCB1 rs1045642 is not a significant genetic factor.

引用

页码：101 / 110

页数：10

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