Hormetic-like dose-response induced by alternagin-C, a protein isolated from urutu snake (Rhinocerophis alternatus) venom, in fish (Hoplias malabaricus) cardiac contractility

被引：1
|
作者：
Monteiro, Diana Amaral [1 ]
Kalinin, Ana Lucia [1 ]
Selistre-de-Araujo, Heloisa Sobreiro [1 ]
Rantin, Francisco Tadeu [1 ]
机构：
[1] Univ Fed Sao Carlos UFSCar, Ctr Ciencias Biol & Saude CCBS, Dept Ciencias Fisiol DCF, BR-13565905 Sao Carlos, SP, Brazil
来源：
TOXICON | 2022年 / 205卷
基金：
巴西圣保罗研究基金会;
关键词：
Cardiac function; Disintegrin-like protein; Rhinocerophis alternatus venom; Hoplias malabaricus; Myocardial contractile force; DISINTEGRIN-LIKE PROTEIN; CYS-RICH PROTEIN; BOTHROPS-ALTERNATUS; ALT-C; SARCOPLASMIC-RETICULUM; MIGRATION;
D O I：
10.1016/j.toxicon.2021.11.123
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of this study was to evaluate the effects of different doses of alternagin-C, a disintegrin-like protein from Rhinocerophis alternatus venom, on myocardial contractility of the freshwater fish Hoplias malabaricus, an alternative model to contractile function studies. Alternagin-C treatment exhibited a hormetic-like dose-response curve with a strong positive inotropism and enhanced cardiac pumping capacity at low dose, whereas a modest inotropism and a left shift in the force-frequency relationship was registered at high dose.
引用
收藏
页码：67 / 70
页数：4
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