Engineering virus-like particles as vaccine platforms

被引：171

作者：

Frietze, Kathryn M. ^{[1
]}

Peabody, David S. ^{[1
]}

Chackerian, Bryce ^{[1
]}

机构：

[1] Univ New Mexico, Sch Med, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA

来源：

CURRENT OPINION IN VIROLOGY | 2016年 / 18卷

基金：

美国国家卫生研究院;

关键词：

EPITOPE-BASED VACCINES; B-CELL RESPONSES; COAT PROTEIN; IMMUNOGENIC DISPLAY; AFFINITY SELECTION; THERMAL-STABILITY; DIVERSE PEPTIDES; ANTIGEN; DESIGN; BACTERIOPHAGE-MS2;

D O I：

10.1016/j.coviro.2016.03.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Virus-like particles (VLPs) have been utilized as vaccine platforms to increase the immunogenicity of heterologous antigens. A variety of diverse VLP types can serve as vaccine platforms, and research has focused on engineering VLPs to improve their efficacy as vaccines, enhance their stability, and allow for more versatile display of antigens. Here, we review selected VLP vaccine platforms, highlight efforts to improve these platforms through structure-informed rational design, and point to areas of future research that will assist in these efforts.

引用

页码：44 / 49

页数：6

共 55 条

[1] A vaccine for hypertension based on virus-like particles:: preclinical efficacy and phase I safety and immunogenicity [J].

Ambuehl, Patrice M. ;

Tissot, Alain C. ;

Fulurija, Alma ;

Maurer, Patrik ;

Nussberger, Juerg ;

Sabat, Robert ;

Nief, Vera ;

Schellekens, Charlotte ;

Sladko, Katja ;

Roubicek, Kirsten ;

Pfister, Thomas ;

Rettenbacher, Manfred ;

Volk, Hans-Dieter ;

Wagner, Frank ;

Mueller, Philipp ;

Jennings, Gary T. ;

Bachmann, Martin F. .

JOURNAL OF HYPERTENSION, 2007, 25 (01) :63-72

[2] Engineering thermal stability in RNA phage capsids via disulphide bonds [J].

Ashcroft, AE ;

Lago, H ;

Macedo, JMB ;

Horn, WT ;

Stonehouse, NJ ;

Stockley, PG .

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2005, 5 (12) :2034-2041

[3] Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns [J].

Bachmann, Martin F. ;

Jennings, Gary T. .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (11) :787-796

[4] THE INFLUENCE OF ANTIGEN ORGANIZATION ON B-CELL RESPONSIVENESS [J].

BACHMANN, MF ;

ROHRER, UH ;

KUNDIG, TM ;

BURKI, K ;

HENGARTNER, H ;

ZINKERNAGEL, RM .

SCIENCE, 1993, 262 (5138) :1448-1451

[5] Neutralizing antiviral B cell responses [J].

Bachmann, MF ;

Zinkernagel, RM .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :235-270

[6] Combinatorial approach to hepadnavirus-like particle vaccine design [J].

Billaud, JN ;

Peterson, D ;

Barr, M ;

Chen, A ;

Sallberg, M ;

Garduno, F ;

Goldstein, P ;

McDowell, W ;

Hughes, J ;

Jones, J ;

Milich, D .

JOURNAL OF VIROLOGY, 2005, 79 (21) :13656-13666

[7] Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization [J].

Brune, Karl D. ;

Leneghan, Darren B. ;

Brian, Iona J. ;

Ishizuka, Andrew S. ;

Bachmann, Martin F. ;

Draper, Simon J. ;

Biswas, Sumi ;

Howarth, Mark .

SCIENTIFIC REPORTS, 2016, 6

[8] Malaria vaccine based on self-assembling protein nanoparticles [J].

Burkhard, Peter ;

Lanar, David E. .

EXPERT REVIEW OF VACCINES, 2015, 14 (12) :1525-1527

[9] Epitope-Specific Anti-hCG Vaccines on a Virus Like Particle Platform [J].

Caldeira, Jerri ;

Bustos, Jeremiah ;

Peabody, Julianne ;

Chackerian, Bryce ;

Peabody, David S. .

PLOS ONE, 2015, 10 (10)

[10] Thermal Stability of RNA Phage Virus-Like Particles Displaying Foreign Peptides [J].

Caldeira, Jerri C. ;

Peabody, David S. .

JOURNAL OF NANOBIOTECHNOLOGY, 2011, 9

← 1 2 3 4 5 6 →