Metabolism of phenanthrene, benz[a]anthracene, benzo[a]pyrene, chrysene and benzo[c]phenanthrene by eight cDNA-expressed human and rat cytochromes P450

被引：23

作者：

Jacob, J

Doehmer, J

Grimmer, G

Soballa, V

Raab, G

Seidel, A

Greim, H

机构：

[1] BIOCHEM INST ENVIRONM CARCINOGENS,D-22927 GROSSHANSDORF,GERMANY

[2] TECH UNIV MUNICH,INST TOXIKOL & UMWELTHYG,D-80636 MUNICH,GERMANY

[3] GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT GMBH,INST TOXIKOL,D-85758 OBERSCHLEISSHEIM,GERMANY

[4] UNIV MAINZ,INST TOXICOL,D-6500 MAINZ,GERMANY

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 1996年 / 10卷 / 1-4期

关键词：

CYP450; isoforms; phenanthrene; benz[a]anthracene; chrysene; benzo[c]phenanthrene; benzo[a]pyrene;

D O I：

10.1080/10406639608034673

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phenanthrene, benz[a]anthracene, chrysene, benzo[c]phenanthrene, and benzo[a]pyrene have been studied for their regiospecific oxidation by five human (1A1, 1A2, 2A6, 2E1, 3A4) and three rat (1A1, 1A2, 2B1) CYP isoforms. All substrates are preferentially metabolized by CYP1A1 and CYP1A2 in human and rat. Other isoforms play a minor role if at all. Significant differences between human and rat CYP isoforms can be recognized with regard to the regiospecific oxidation of PAH. For instance, K-region oxidation is more pronounced in rat than in human CYP1A1 and CYP1A2. Hence, extrapolation from metabolism studies in rodents to human may be limited.

引用

页码：1 / 9

页数：9

共 21 条

[1] OXIDATION OF BENZO[A]PYRENE BY RECOMBINANT HUMAN CYTOCHROME-P450 ENZYMES [J].