Peptides and peptidomimetics as therapeutic agents for Covid-19

被引：11

作者：

Dahal, Achyut ^{[1
]}

Sonju, Jafrin Jobayer ^{[1
]}

Kousoulas, Konstantin G. ^{[2
]}

Jois, Seetharama D. ^{[1
]}

机构：

[1] Univ Louisiana, Sch Basic Pharmaceut & Toxicol Sci, Coll Pharm, Monroe, LA 71201 USA

[2] Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA USA

来源：

PEPTIDE SCIENCE | 2022年 / 114卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Covid-19; peptides; peptidomimetics; protein-protein interaction; SARS-CoV-2; PROTEIN-PROTEIN INTERACTIONS; SARS-COV-2 SPIKE PROTEIN; CORONAVIRUS; DESIGN; INHIBITION; ENTRY; ACE2; MIMICKING; INFECTION; DISCOVERY;

D O I：

10.1002/pep2.24245

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Covid-19 pandemic has caused high morbidity and mortality rates worldwide. Virus entry into cells can be blocked using several strategies, including inhibition of protein-protein interactions (PPIs) between the viral spike glycoprotein and cellular receptors, as well as blocking of spike protein conformational changes that are required for cleavage/activation and fusogenicity. The spike-mediated viral attachment and entry into cells via fusion of the viral envelope with cellular membranes involve PPIs mediated by short peptide fragments exhibiting particular secondary structures. Thus, peptides that can inhibit these PPIs may be used as potential antiviral agents preventing virus entry and spread. This review is focused on peptides and peptidomimetics as PPI modulators and protease inhibitors against SARS-CoV-2.

引用

页数：16

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