Early risk warning system for distant metastasis of hepatitis B virus-associated hepatocellular carcinoma with portal vein tumor thrombus

被引:10
作者
Li, Mengge [1 ,2 ]
Zhao, Yalin [3 ]
Liu, Xiaoli [1 ]
Zhang, Shuan [1 ]
Jiang, Yuyong [1 ]
Yang, Zhiyun [1 ]
机构
[1] Capital Med Univ, Beijing Ditan Hosp, Ctr Integrat Med, 8 Jingshun East St, Beijing 100015, Peoples R China
[2] Henan Prov Hosptial Tradit Chinese Med, Dept Hepatobiliary Spleen & Stomach, Zhengzhou 450002, Henan, Peoples R China
[3] Peoples Hosp Hebi, Dept Gastroenterol & Hematol Med, Hebi 450000, Henan, Peoples R China
关键词
hepatitis B virus; primary hepatocellular carcinoma; portal vein tumor thrombus; distant metastasis; risk warning model; TO-LYMPHOCYTE RATIO; PROGNOSTIC-FACTOR; SURVIVAL BENEFIT; NATURAL-HISTORY; MACROPHAGES; NEUTROPHIL; RESECTION; ERYTHROPOIESIS;
D O I
10.3892/ol.2020.11423
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with PVTT. Data from 346 patients (263 and 83 in the modeling and validation cohorts, respectively) who had received primary diagnoses of HBV-HCC and PVTT between January 2012 and June 2015 at Beijing Ditan Hospital (Beijing, China) were retrospectively examined. In the modeling cohort, univariate and multivariate logistic regression analyses were conducted to determine the factors that were significantly associated with distant metastasis. Furthermore, an early risk warning model for distant metastasis was proposed and validated through receiver operating characteristic curve analysis in the validation cohort. The results revealed that neutrophil to lymphocyte ratios of >= 2.31, red blood cell counts of >= 4.07x10(12) cells/l, C-reactive protein levels of >= 7.02 mg/l, aspartate aminotransferase levels of >= 118.5 U/l and tumor thrombus site (at branch) were significantly positively associated with distant metastasis of HBV-HCC with PVTT (P1.000). A formula for predicting distant metastasis was obtained with an accuracy of 70%. The results of the present study may allow for the early prediction of distant metastasis and facilitate the administration of appropriate treatment to improve the outcomes and prognosis of patients with intermediate to advanced HCC.
引用
收藏
页码:3249 / 3257
页数:9
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