Lactulose: An indirect antioxidant ameliorating inflammatory bowel disease by increasing hydrogen production

被引：53

作者：

Chen, Xiao ^{[2
]}

Zuo, Qiao ^{[2
]}

Hai, Yuedong ^{[3
]}

Sun, Xue Jun ^{[1
]}

机构：

[1] Second Mil Med Univ, Fac Naval Med, Dept Div Med, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Grad Management Unit, Shanghai 200433, Peoples R China

[3] Second Mil Med Univ, Changzheng Hosp, Shanghai 200433, Peoples R China

来源：

MEDICAL HYPOTHESES | 2011年 / 76卷 / 03期

关键词：

METABOLISM; INHALATION; THERAPY; COLITIS; MODEL; COLON; ACTS;

D O I：

10.1016/j.mehy.2010.09.026

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Lactulose, which cannot be digested and absorbed by body, is clinically widely used to treat constipation and hepatic encephalopathy. Fermented by gastrointestinal tract bacteria, lactulose can produce considerable amount of hydrogen, which is protective for DSS-induced colitis as a unique antioxidant. We propose that lactulose is an indirect antioxidant that mobilizes endogenous hydrogen production which in turn can reduce oxidative stress and ameliorate symptoms of inflammatory bowel disease in human beings. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：325 / 327

页数：3

共 27 条

[1] CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease [J].

Barnich, Nicolas ;

Carvalho, Frederic A. ;

Glasser, Anne-Lise ;

Darcha, Claude ;

Jantscheff, Peter ;

Allez, Matthieu ;

Peeters, Harald ;

Bommelaer, Gilles ;

Desreumaux, Pierre ;

Colombel, Jean-Frederic ;

Darfeuille-Michaud, Arlette .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (06) :1566-1574

[2] Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury [J].

Buchholz, B. M. ;

Kaczorowski, D. J. ;

Sugimoto, R. ;

Yang, R. ;

Wang, Y. ;

Billiar, T. R. ;

McCurry, K. R. ;

Bauer, A. J. ;

Nakao, A. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (10) :2015-2024

[3] Evaluation of new therapies for inflammatory bowel disease [J].

Carty, E ;

Rampton, DS .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 56 (04) :351-361

[4] Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats [J].

Chen, Han ;

Sun, Yan Ping ;

Li, Yang ;

Liu, Wen Wu ;

Xiang, Hong Gang ;

Fan, Lie Ying ;

Sun, Qiang ;

Xu, Xin Yun ;

Cai, Jian Mei ;

Ruan, Can Ping ;

Su, Ning ;

Yan, Rong Lin ;

Sun, Xue Jun ;

Wang, Qiang .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 393 (02) :308-313

[5] Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota [J].

Elson, CO ;

Cong, Y ;

McCracken, VJ ;

Dimmitt, RA ;

Lorenz, RG ;

Weaver, CT .

IMMUNOLOGICAL REVIEWS, 2005, 206 :260-276

[6] Long-Term Antibiotic Treatment for Crohn's Disease: Systematic Review and Meta-Analysis of Placebo-Controlled Trials [J].

Feller, Martin ;

Huwiler, Karin ;

Schoepfer, Alain ;

Shang, Aijing ;

Furrer, Hansjakob ;

Egger, Matthias .

CLINICAL INFECTIOUS DISEASES, 2010, 50 (04) :473-480

[7] INFLUENCE OF CHRONIC LACTULOSE INGESTION ON THE COLONIC METABOLISM OF LACTULOSE IN MAN (AN INVIVO STUDY) [J].

FLORENT, C ;

FLOURIE, B ;

LEBLOND, A ;

RAUTUREAU, M ;

BERNIER, JJ ;

RAMBAUD, JC .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 75 (02) :608-613

[8] Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress [J].

Fukuda, Kei-Ichi ;

Asoh, Sadamitsu ;

Ishikawa, Masahiro ;

Yamamoto, Yasuhiro ;

Ohsawa, Ikuroh ;

Ohta, Shigeo .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 361 (03) :670-674

[9] Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation [J].

Gharib, B ;

Hanna, S ;

Abdallahi, OMS ;

Lepidi, H ;

Gardette, B ;

De Reggi, M .

COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES, 2001, 324 (08) :719-724

[10] NF-κB activation by reactive oxygen species:: Fifteen years later [J].

Gloire, Geoffrey ;

Legrand-Poels, Sylvie ;

Piette, Jacques .

BIOCHEMICAL PHARMACOLOGY, 2006, 72 (11) :1493-1505

← 1 2 3 →