1,5-anhydro-2-deoxy-D-altritol oligonucleotides as conformationally restricted analogues of RNA

被引：3
|
作者：
Allart, B [1 ]
Van Aerschot, A [1 ]
Herdewijn, P [1 ]
机构：
[1] Katholieke Univ Leuven, Rega Inst Med Res, Med Chem Lab, B-3000 Louvain, Belgium
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1998年 / 17卷 / 9-11期
关键词：
D O I：
10.1080/07328319808004682
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As part of a project concerning the investigation of new hexitol nucleic acids (HNA), the 1,5-anhydro-2-deoxy-D-altritol nucleoside building blacks with a uracil, cytosine, adenine and guanine base moiety were synthesized. The uracil analogue was used for the automated synthesis of corresponding oligonucleotides. Hybridization capabilities of these altritol nucleic acids (ANA) are illustrated by the Tm values obtained for the (a(h)U)(13)/(dA)(13) duplex.
引用
收藏
页码：1523 / 1526
页数：4
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