Mycobacterium avium subsp. paratuberculosis Virulence: A Review

被引：9
|
作者：
Ssekitoleko, Judah [1 ,2 ]
Ojok, Lonzy [1 ,3 ]
Abd El Wahed, Ahmed [4 ]
Erume, Joseph [1 ]
Amanzada, Ahmad [5 ]
Eltayeb, ElSagad [6 ,7 ]
Eltom, Kamal H. [8 ]
Okuni, Julius Boniface [1 ]
机构：
[1] Makerere Univ, Coll Vet Med Anim Resources & Biosecur, POB 7062, Kampala, Uganda
[2] Natl Agr Res Org, Rwebitaba Zonal Agr Res & Dev Inst, Dept Livestock Hlth Res, POB 295, Entebbe, Uganda
[3] Gulu Univ, Fac Med, Dept Pathol, POB 166, Gulu, Uganda
[4] Univ Leipzig, Inst Anim Hyg & Vet Publ Hlth, D-04103 Leipzig, Germany
[5] Univ Med Ctr Goettingen, Dept Gastroenterol & Gastrointestinal Oncol, D-37075 Gottingen, Germany
[6] Ibn Sina Specialised Hosp, Mohammed Najeeb St, Khartoum 11560, Sudan
[7] Al Neelain Univ, Fac Med, 52nd St, Khartoum 11112, Sudan
[8] Univ Khartoum, Inst Studies & Promot Anim Exports, Unit Anim Hlth & Safety Anim Prod, Shambat 13314, Khartoum North, Sudan
来源：
MICROORGANISMS | 2021年 / 9卷 / 12期
关键词：
Mycobacterium avium subspecies paratuberculosis; Johne's disease; virulence; pathogenesis; CYTOKINE GENE-EXPRESSION; HERD-LEVEL PREVALENCE; PROTEIN-KINASE-G; NITRIC-OXIDE; BOVINE MACROPHAGES; PERIPHERAL-BLOOD; JOHNES-DISEASE; IN-VITRO; INTRACELLULAR SURVIVAL; SIGMA-FACTOR;
D O I：
10.3390/microorganisms9122623
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
To propose a solution for control of Mycobacterium avium subsp. paratuberculosis (MAP) infections in animals as well as in humans, and develop effective prevention, diagnostic and treatment strategies, it is essential to understand the molecular mechanisms of MAP pathogenesis. In the present review, we discuss the mechanisms utilised by MAP to overcome the host defense system to achieve the virulence status. Putative MAP virulence genes are mentioned and their probable roles in view of other mycobacteria are discussed. This review provides information on MAP strain diversity, putative MAP virulence factors and highlights the knowledge gaps regarding MAP virulence mechanisms that may be important in control and prevention of paratuberculosis.
引用
收藏
页数：16
相关论文
共 50 条
  • [21] A Mycobacterium avium subsp paratuberculosis LuxR regulates cell envelope and virulence
    Alonso-Hearn, Marta
    Eckstein, Torsten M.
    Sommer, Sandra
    Bermudez, Luiz E.
    INNATE IMMUNITY, 2010, 16 (04) : 235 - 247
  • [22] In Vivo Volatile Organic Compound Signatures of Mycobacterium avium subsp. paratuberculosis
    Bergmann, Andreas
    Trefz, Phillip
    Fischer, Sina
    Klepik, Klaus
    Walter, Gudrun
    Steffens, Markus
    Ziller, Mario
    Schubert, Jochen K.
    Reinhold, Petra
    Koehler, Heike
    Miekisch, Wolfram
    PLOS ONE, 2015, 10 (04):
  • [23] Immunoreactivity of the Mycobacterium avium subsp. paratuberculosis 19-kDa lipoprotein
    Jason FJ Huntley
    Judith R Stabel
    John P Bannantine
    BMC Microbiology, 5
  • [24] Detection of Mycobacterium avium subsp.: paratuberculosis in goat and sheep flocks in Mexico
    Estevez-Denaives, I.
    Hernandez-Castro, R.
    Trujillo-Garcia, A. M.
    Chavez-Gris, G.
    SMALL RUMINANT RESEARCH, 2007, 72 (2-3) : 209 - 213
  • [25] Mycobacterium avium subsp. paratuberculosis and Hashimoto's thyroiditis: Is MAP the trigger?
    Moghadam, Maedeh
    Ghaemi, Ezzat Allah
    Akbari, Hamideh
    Razavi Nikoo, Hadi
    Zamani, Samin
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2022, 12
  • [26] An eco-friendly decontaminant to kill Mycobacterium avium subsp. paratuberculosis
    Stabel, J. R.
    Turner, A.
    Walker, M.
    JOURNAL OF MICROBIOLOGICAL METHODS, 2020, 176
  • [27] Genotyping methods and molecular epidemiology of Mycobacterium avium subsp. paratuberculosis (MAP)
    Fawzy, Ahmad
    Zschoeck, Michael
    Ewers, Christa
    Eisenberg, Tobias
    INTERNATIONAL JOURNAL OF VETERINARY SCIENCE AND MEDICINE, 2018, 6 (02) : 258 - 264
  • [28] Mycobacterium avium subsp. paratuberculosis in Wild Boar (Sus scrofa) in Portugal
    Matos, Ana Cristina
    Figueira, Luis
    Martins, Maria Helena
    Cardoso, Luis
    Matos, Manuela
    Pinto, Maria de Lurdes
    Coelho, Ana Claudia
    PATHOGENS, 2024, 13 (05):
  • [29] PCR-restriction endonuclease analysis for identification and strain typing of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium based on polymorphisms in IS1311
    Marsh, I
    Whittington, R
    Cousins, D
    MOLECULAR AND CELLULAR PROBES, 1999, 13 (02) : 115 - 126
  • [30] Culture of Mycobacterium avium subsp. paratuberculosis: challenges, limitations and future prospects
    Dane, Hannah
    Stewart, Linda D.
    Grant, Irene R.
    JOURNAL OF APPLIED MICROBIOLOGY, 2023, 134 (01)
12345