Mycobacterium avium subsp. paratuberculosis Virulence: A Review

被引：13

作者：

Ssekitoleko, Judah ^{[1
,2
]}

Ojok, Lonzy ^{[1
,3
]}

Abd El Wahed, Ahmed ^{[4
]}

Erume, Joseph ^{[1
]}

Amanzada, Ahmad ^{[5
]}

Eltayeb, ElSagad ^{[6
,7
]}

Eltom, Kamal H. ^{[8
]}

Okuni, Julius Boniface ^{[1
]}

机构：

[1] Makerere Univ, Coll Vet Med Anim Resources & Biosecur, POB 7062, Kampala, Uganda

[2] Natl Agr Res Org, Rwebitaba Zonal Agr Res & Dev Inst, Dept Livestock Hlth Res, POB 295, Entebbe, Uganda

[3] Gulu Univ, Fac Med, Dept Pathol, POB 166, Gulu, Uganda

[4] Univ Leipzig, Inst Anim Hyg & Vet Publ Hlth, D-04103 Leipzig, Germany

[5] Univ Med Ctr Goettingen, Dept Gastroenterol & Gastrointestinal Oncol, D-37075 Gottingen, Germany

[6] Ibn Sina Specialised Hosp, Mohammed Najeeb St, Khartoum 11560, Sudan

[7] Al Neelain Univ, Fac Med, 52nd St, Khartoum 11112, Sudan

[8] Univ Khartoum, Inst Studies & Promot Anim Exports, Unit Anim Hlth & Safety Anim Prod, Shambat 13314, Khartoum North, Sudan

来源：

MICROORGANISMS | 2021年 / 9卷 / 12期

关键词：

Mycobacterium avium subspecies paratuberculosis; Johne's disease; virulence; pathogenesis; CYTOKINE GENE-EXPRESSION; HERD-LEVEL PREVALENCE; PROTEIN-KINASE-G; NITRIC-OXIDE; BOVINE MACROPHAGES; PERIPHERAL-BLOOD; JOHNES-DISEASE; IN-VITRO; INTRACELLULAR SURVIVAL; SIGMA-FACTOR;

D O I：

10.3390/microorganisms9122623

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To propose a solution for control of Mycobacterium avium subsp. paratuberculosis (MAP) infections in animals as well as in humans, and develop effective prevention, diagnostic and treatment strategies, it is essential to understand the molecular mechanisms of MAP pathogenesis. In the present review, we discuss the mechanisms utilised by MAP to overcome the host defense system to achieve the virulence status. Putative MAP virulence genes are mentioned and their probable roles in view of other mycobacteria are discussed. This review provides information on MAP strain diversity, putative MAP virulence factors and highlights the knowledge gaps regarding MAP virulence mechanisms that may be important in control and prevention of paratuberculosis.

引用

页数：16

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