Tight junctions in cancer metastasis

被引：83

作者：

Martin, Tracey A. ^{[1
]}

Mason, Malcolm D. ^{[1
]}

Jiang, Wen G. ^{[1
]}

机构：

[1] Cardiff Univ, Metastasis & Angiogenesis Res Grp, Dept Surg, Sch Med, Cardiff CF14 4XN, S Glam, Wales

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2011年 / 16卷

关键词：

Tight Junction; Barrier function; Cancer; Metastasis; Review; SQUAMOUS-CELL CARCINOMA; HUMAN BREAST-CANCER; CLOSTRIDIUM-PERFRINGENS ENTEROTOXIN; VASCULAR ENDOTHELIAL-CELLS; EPITHELIAL OVARIAN-CANCER; TRANSENDOTHELIAL RESISTANCE TER; COXSACKIE-ADENOVIRUS RECEPTOR; PARACELLULAR BARRIER FUNCTION; HUMAN ENDOMETRIAL CARCINOMA; GROWTH-FACTOR RECEPTOR;

D O I：

10.2741/3726

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tight Junctions (TJ) are well known to function as a control for the paracellular diffusion of ions and certain molecules, it has however, become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ structure can lead to invasion and ultimately to the metastasis of cancer cells. This review will discuss how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the progression of cancer and progression of metastasis.

引用

页码：898 / 936

页数：39

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