Some studies in cyanine dyes incorporating pyridine rings endowed with pharmaceutical potency

We report the synthesis of new series of methine cyanine dyes 1, 3-13which have been obtained by the one-pot step reaction of quaternized heterocyclic compound 2 with benzenaminium salt 1 under various methodology technique. (E)-N-(((E)-2-Chloro-3-((phenylamino)methylene)cyclopent-1-enyl)methylene) benzenaminium chloride (I) was synthesized by the reaction of cyclopentanone with Vilsmeier-Haack reagent, then a mixture of an equimolar ratio of aniline: ethanol (1:1) was added to give the target compound. All the synthesized compounds were subjected to in vitro anticancer screening against two cell lines, human cervix carcinoma cell line and human breast carcinoma cell line. Some of these compounds were found to be equipotent or more potentthan commercial anticancer as an evident from the results. (C) 2015 Elsevier Ltd. All rights reserved.