The host response to anthrax lethal toxin: unexpected observations

被引：20
|
作者：
Prince, AS [1 ]
机构：
[1] Columbia Univ Coll Phys & Surg, Dept Pediat, New York, NY 10032 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 05期
关键词：
D O I：
10.1172/JC1200319581
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Bacillus anthracis, the causative agent of anthrax, is believed to induce disease and death in humans in an endotoxic shock-like manner. A comprehensive study (see the related article beginning on page 670) of the effects of anthrax toxin in mice demonstrates that toxin-induced death is mediated not by cytokine release, as previously thought, but by hypoxia-induced liver failure. The study strongly suggests that the therapies developed for treatment of cytokine-mediated septic shock will not be appropriate for the treatment of anthrax.
引用
收藏
页码：656 / 658
页数：3
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