Alpha-1 antitrypsin deficiency: An underrecognized, treatable cause of COPD

被引：10

作者：

Stoller, James K. ^{[1
,2
]}

机构：

[1] Cleveland Clin, Inst Educ, NA2,9500 Euclid Ave, Cleveland, OH 44195 USA

[2] Case Western Reserve Univ, Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA

来源：

CLEVELAND CLINIC JOURNAL OF MEDICINE | 2016年 / 83卷 / 07期

关键词：

ALPHA(1)-ANTITRYPSIN DEFICIENCY; LUNG-FUNCTION; AUGMENTATION THERAPY; CT DENSITOMETRY; DISEASE; IMPACT; INDIVIDUALS; DIAGNOSIS; POLYMERS; REGISTRY;

D O I：

10.3949/ccjm.83a.16031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alpha-1 antitrypsin deficiency is common but underrecognized. Because delayed diagnosis is thought to be associated with adverse outcomes, clinicians are encouraged to follow available guidelines and test for the disease in all symptomatic adults with fixed airflow obstruction. The weight of available evidence supports the biochemical and clinical efficacy of intravenous augmentation therapy. Promising new therapies are being investigated.

引用

页码：507 / 514

页数：8

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