Comprehensive review of ASC structure and function in immune homeostasis and disease

被引：25

作者：

Agrawal, Ishan ^{[1
]}

Jha, Sushmita ^{[1
]}

机构：

[1] Indian Inst Technol Jodhpur, Dept Biosci & Bioengn, NH 65,Nagaur Rd, Jodhpur 342037, Rajasthan, India

来源：

MOLECULAR BIOLOGY REPORTS | 2020年 / 47卷 / 04期

关键词：

ASC; Inflammasome; Inflammation; Pyroptosis; Cancer; NLR; SPECK-LIKE PROTEIN; CASPASE RECRUITMENT DOMAIN; NLRP3; INFLAMMASOME; CELL-DEATH; ABERRANT METHYLATION; NMR STRUCTURE; CUTTING EDGE; PYRIN DOMAIN; CARD ASC; EPIGENETIC INACTIVATION;

D O I：

10.1007/s11033-020-05345-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis associated speck like protein containing CARD (ASC) is widely researched and recognized as an adaptor protein participating in inflammasome assembly and pyroptosis. It contains a bipartite structure comprising of a pyrin and a caspase recruitment domain (CARD) domain. These two domains help ASC function as an adaptor molecule. ASC is encoded by the gene PYCARD. ASC plays pivotal role in various diseases as well as different homeostatic processes. ASC plays a regulatory role in different cancers showing differential regulation with respect to tissue and stage of disease. Besides cancer, ASC also plays a central role in sensing, regulation, and/or disease progression in bacterial infections, viral infections and in varied inflammatory diseases. ASC is expressed in different types of immune and non-immune cells. Its localization pattern also varies with different kinds of stimuli encountered by cell. This review will summarize the literature on the structure cellular and tissue expression, localization and disease association of ASC.

引用

页码：3077 / 3096

页数：20

共 147 条

[41] The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation [J].

Franklin, Bernardo S. ;

Bossaller, Lukas ;

De Nardo, Dominic ;

Ratter, Jacqueline M. ;

Stutz, Andrea ;

Engels, Gudrun ;

Brenker, Christoph ;

Nordhoff, Mark ;

Mirandola, Sandra R. ;

Al-Amoudi, Ashraf ;

Mangan, Matthew S. ;

Zimmer, Sebastian ;

Monks, Brian G. ;

Fricke, Martin ;

Schmidt, Reinhold E. ;

Espevik, Terje ;

Jones, Bernadette ;

Jarnicki, Andrew G. ;

Hansbro, Philip M. ;

Busto, Patricia ;

Marshak-Rothstein, Ann ;

Hornemann, Simone ;

Aguzzi, Adriano ;

Kastenmueller, Wolfgang ;

Latz, Eicke .

NATURE IMMUNOLOGY, 2014, 15 (08) :727-+

[42]

Furlan R, 1999, J IMMUNOL, V163, P2403

[43] Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets [J].

Furuhashi, Masato ;

Hotamisligil, Goekhan S. .

NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (06) :489-503

[44] Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture [J].

Garwood, C. J. ;

Pooler, A. M. ;

Atherton, J. ;

Hanger, D. P. ;

Noble, W. .

CELL DEATH & DISEASE, 2011, 2 :e167-e167

[45]

Gordian E, 2009, ANTICANCER RES, V29, P3207

[46] NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses [J].

Gris, Denis ;

Ye, Zhengmao ;

Iocca, Heather A. ;

Wen, Haitao ;

Craven, Robin R. ;

Gris, Pavel ;

Huang, Max ;

Schneider, Monika ;

Miller, Stephen D. ;

Ting, Jenny P. -Y. .

JOURNAL OF IMMUNOLOGY, 2010, 185 (02) :974-981

[47] Immunity, Inflammation, and Cancer [J].

Grivennikov, Sergei I. ;

Greten, Florian R. ;

Karin, Michael .

CELL, 2010, 140 (06) :883-899

[48] ASC/TMS1, A caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma [J].

Guan, X ;

Sagara, J ;

Yokoyama, T ;

Koganehira, Y ;

Oguchi, M ;

Saida, T ;

Taniguchi, S .

INTERNATIONAL JOURNAL OF CANCER, 2003, 107 (02) :202-208

[49] Inflammasomes: mechanism of action, role in disease, and therapeutics [J].

Guo, Haitao ;

Callaway, Justin B. ;

Ting, Jenny P-Y .

NATURE MEDICINE, 2015, 21 (07) :677-687

[50] Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF-κB Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor [J].

Harder, Juergen ;

Franchi, Luigi ;

Munoz-Planillo, Raul ;

Park, Jong-Hwan ;

Reimer, Thornik ;

Nunez, Gabriel .

JOURNAL OF IMMUNOLOGY, 2009, 183 (09) :5823-5829

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