Detection of bcr/abl mRNA in a case of chronic myelogenous leukemia in long-term remission:: CML or sensitivity of detection?

被引:0
作者
Anguita, E [1 ]
Villegas, A [1 ]
Díaz-Mediavilla, J [1 ]
González, FA [1 ]
Del Potro, E [1 ]
Espinós, D [1 ]
机构
[1] Hosp Univ San Carlos, Dept Hematol, Madrid 28040, Spain
关键词
chronic myelogenous leukaemia; BCR/ABL; nested RT-PCR; Southern blot; remission; prolonged survival;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder which, after a chronic phase which lasts an average of 3 years, evolves Into an acute disease which is resistant to chemotherapy. Nevertheless, a few studies have reported cases In which partial or complete hematologic, cytogenetic and/or molecular remission of the disease were observed either spontaneously or after non intensive chemotherapy, with or without medullar aplasia. Some of these patients later relapsed into a blast crisis. We report a case of CML with clinical and hematologic remission for 19 years after two cycles of busulphan not causing medullar aplasia, negative for the BCR/ABL gene by Southern blot but with the gene's mRNA detectable by hot start nested RT-PCR. (C) 1998, Ferrata Storti Foundation.
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页码:744 / 747
页数:4
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