Enantiomerically convergent synthesis of phosphatidyl-D-myo-inositol 3,5-bisphosphate from both L- and D-1,2-0-cyclohexylidene-myo-inositol

被引：7

作者：

Han, FS

Hayashi, M

Watanabe, Y ^{[1
]}

机构：

[1] Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan

[2] Ehime Univ, Fac Engn, Dept Appl Chem, Matsuyama, Ehime 7908577, Japan

来源：

CHEMISTRY LETTERS | 2003年 / 32卷 / 08期

关键词：

D O I：

10.1246/cl.2003.724

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of phosphatidyl-D-myo-inositol 3,5-bisphosphate [PtdIns(3,5)P2] has been conveniently accomplished via convergent routes starting from both enantiomers, 1,2-O-cyclohexylidene-myo-inositol. The synthetic strategy involves completely regioselective phosphorylation of 3,4-diol and 2,3,6-triol of the suitably protected inositols with the corresponding phosphite in the presence of pyridinium tribromide and 2,6-lutidine, resulting in the formation of 3-O-phosphorylated products, respectively.

引用

页码：724 / 725

页数：2

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