SIMPLE AND EFFICIENT ONE POT SYNTHETIC PROTOCOL TO CONSTRUCT MORPHOLIN-2-ONES

被引：2
作者：
Yellol, Gorakh S. [1 ]
Mohapatra, Debendra K. [2 ]
Gurjar, Mukund K. [3 ]
Sun, Chung-Ming [1 ]
机构：
[1] Natl Chiao Tung Univ, Dept Appl Chem, Hsinchu 30010, Taiwan
[2] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India
[3] Emcure Pharmaceut Ltd, Pune 411057, Maharashtra, India
来源：
HETEROCYCLES | 2010年 / 82卷 / 01期
关键词：
Amino Acid; One Pot Synthesis; Morpholin-2-one; Three Component Reaction; Dibromoethane; ALPHA-AMINO-ACIDS; NK1 RECEPTOR ANTAGONIST; N-HETEROCYCLES; STEREOSELECTIVE-SYNTHESIS; PROTEASE INHIBITORS; CONVERGENT APPROACH; MULTISTEP SYNTHESIS; DERIVATIVES; APREPITANT; STRATEGY;
D O I：
10.3987/COM-10-S(E)14
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new one pot synthetic method to construct 3-substituted morpholine-2-one derivatives is presented. Amino acids refluxed with 1,2-dibromoethane and potassium carbonate in acetonitrile followed by treatment with benzyl bromide in same pot furnished the 3-substituted N-benzyl-morpholine-2-ones in good yields. The simplicity of the reaction conditions and versatility of resulted scaffold to generate wide variety of molecules makes this method more attractive for synthetic organic chemists.
引用
收藏
页码：431 / 439
页数：9
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