Catalytic deprotection of Acetals in basic solution with a self-assembled supramolecular "Nanozyme"

被引：95

作者：

Pluth, Michael D. ^{[1
]}

Bergman, Robert G. ^{[1
]}

Raymond, Kenneth N. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 45期

关键词：

cage compounds; homogeneous catalysis; host-guest systems; protecting groups; supramolecular chemistry;

D O I：

10.1002/anie.200703371

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Formula Presented) Changing on the inside: Acetals are a commonly used protecting groups for aldehydes and ketones in organic synthesis because of their ease of installation and resistance to cleavage in neutral or basic solution. A self-assembled supramolecular assembly has been shown to catalyze the hydrolysis of acetals and ketals in basic solution (see scheme). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8587 / 8589

页数：3

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