Building Addressable Libraries: The Use of "Safety-Catch" Linkers on Microelectrode Arrays

被引：7
作者：
Bi, Bo [1 ]
Maurer, Karl [2 ]
Moeller, Kevin D. [1 ]
机构：
[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA
[2] CustomArray Inc, Mukilteo, WA 98275 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 49期
基金：
美国国家科学基金会;
关键词：
SPECTROMETRY-CLEAVABLE LINKER; PEPTIDE-SYNTHESIS; CHIP; ELECTROCHEMISTRY; ACID;
D O I：
10.1021/ja109253t
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A "safety-catch" linker strategy has been used to site-selectively cleave and characterize molecules from a microelectrode array. The linkers are attached to the array by means of an ester and contain either a protected amine or protected alcohol nucleophile that can be released using acid generated at the microelectrodes.
引用
收藏
页码：17405 / 17407
页数：3
相关论文
共 22 条
[1]   Building addressable libraries: a site-selective click-reaction strategy for rapidly assembling mass spectrometry cleavable linkers [J].
Bartels, Jennifer L. ;
Lu, Peng ;
Walker, Amy ;
Maurer, Karl ;
Moeller, Kevin D. .
CHEMICAL COMMUNICATIONS, 2009, (37) :5573-5575
[2]   Building Addressable Libraries: Site-Selective Lewis Acid (Scandium(III)) Catalyzed Reactions [J].
Bi, Bo ;
Maurer, Karl ;
Moeller, Kevin D. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (32) :5872-5874
[3]   The use of a detectable, mass-spectrometry-cleavable linker for quality control on an addressable microelectrode array [J].
Chen, Ceng ;
Lu, Peng ;
Walker, Amy ;
Maurer, Karl ;
Moeller, Kevin D. .
ELECTROCHEMISTRY COMMUNICATIONS, 2008, 10 (07) :973-976
[4]   Building addressable libraries: The use of a mass spectrometry cleavable linker for monitoring reactions on a microelectrode array [J].
Chen, Ceng ;
Nagy, Gabriella ;
Walker, Amy V. ;
Maurer, Karl ;
McShea, Andy ;
Moeller, Kevin D. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (50) :16020-16021
[5]   Antigen detection using microelectrode array microchips [J].
Dill, K ;
Montgomery, DD ;
Wang, W ;
Tsai, JC .
ANALYTICA CHIMICA ACTA, 2001, 444 (01) :69-78
[6]  
Hintsche R, 2000, ELECTROANAL, V12, P660, DOI 10.1002/1521-4109(200005)12:9<660::AID-ELAN660>3.0.CO
[7]  
2-#
[8]   A New Porous Reaction Layer for Developing Addressable Molecular Libraries [J].
Hu, Libo ;
Bartels, Jennifer L. ;
Bartels, Jeremy W. ;
Maurer, Karl ;
Moeller, Kevin D. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (46) :16638-+
[9]   Building Addressable Libraries: Site-Selective Suzuki Reactions on Microelectrode Arrays [J].
Hu, Libo ;
Maurer, Karl ;
Moeller, Kevin D. .
ORGANIC LETTERS, 2009, 11 (06) :1273-1276
[10]   SAFETY CATCH PRINCIPLE IN SOLID PHASE PEPTIDE SYNTHESIS [J].
KENNER, GW ;
MCDERMOT.JR ;
SHEPPARD, RC .
JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1971, (12) :636-&
123