Synthesis of Novel Imidazo[1,2-a]pyridin-2-amines from Arylamines and Nitriles via Sequential Addition and I2/KI-Mediated Oxidative Cyclization

被引：28

作者：

Tian, Xianhai ^{[1
]}

Song, Lina ^{[1
]}

Wang, Manman ^{[1
]}

Lv, Zhigang ^{[1
]}

Wu, Jie ^{[1
]}

Yu, Wenquan ^{[1
]}

Chang, Junbiao ^{[1
,2
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Peoples R China

[2] Collaborat Innovat Ctr New Drug Res & Safety Eval, Coll Chem & Mol Engn, Zhengzhou 450001, Henan Province, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 22期

基金：

中国国家自然科学基金;

关键词：

C-N bond formation; iodine; imidazo[1,2-a]pyridin-2-amine; oxidative cyclization; sequential synthesis; DEPENDENT KINASE INHIBITORS; ONE-POT SYNTHESIS; 3-COMPONENT REACTION; STRUCTURAL CLASS; DERIVATIVES; 2-AMINOPYRIDINES; COMPLEXES; DESIGN; FLUORESCENCE; ISOCYANIDES;

D O I：

10.1002/chem.201600849

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and practical strategy for the construction of imidazo[1,2-a]pyridin-2-amine frameworks has been developed. The present sequential approach involves addition of arylamines to nitriles and I-2/KI-mediated oxidative C-N bond formation without purification of the intermediate amidines. This operationally simple synthetic process provides a facile access to a variety of new 2-amino substituted imidazo[1,2-a]pyridines and related heterocyclic compounds in an efficient and scalable fashion.

引用

页码：7617 / 7622

页数：6

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