Gut Microbiota Dysbiosis in Postweaning Piglets: Understanding the Keys to Health

被引：650

作者：

Gresse, Raphaele ^{[1
,2
]}

Chaucheyras-Durand, Frederique ^{[2
]}

Fleury, Mickael Alain ^{[3
]}

Van de Wiele, Tom ^{[4
]}

Forano, Evelyne ^{[1
]}

Blanquet-Diot, Stephanie ^{[1
]}

机构：

[1] UCA, INRA, UMR 454, MEDIS, F-63000 Clermont Ferrand, France

[2] Lallemand Anim Nutr, F-31702 Blagnac, France

[3] Inst Elevage IDELE, F-14310 Villers Bocage, France

[4] Univ Ghent, Ctr Microbial Ecol & Technol, B-9000 Ghent, Belgium

来源：

TRENDS IN MICROBIOLOGY | 2017年 / 25卷 / 10期

关键词：

ESCHERICHIA-COLI F4; DIETARY ZINC-OXIDE; IN-VITRO MODEL; ORGANIC-ACIDS; WEANING PIGS; INTESTINAL MICROBIOTA; FEED SUPPLEMENTATION; BACTERIAL DIVERSITY; IMMUNE-RESPONSE; WEANED PIGLETS;

D O I：

10.1016/j.tim.2017.05.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Weaning is a critical event in the pig's life cycle, frequently associated with severe enteric infections and overuse of antibiotics; this raises serious economic and public health concerns. In this review, we explain why gut micro-biota dysbiosis, induced by abrupt changes in the diet and environment of piglets, emerges as a leading cause of post-weaning diarrhea, even if the exact underlying mechanisms remain unclear. Then, we focus on nonantimi-crobial alternatives, such as zinc oxide, essential oils, and prebiotics or probiotics, which are currently evaluated to restore intestinal balance and allow a better management of the crucial weaning transition. Finally, we discuss how in vitro models of the piglet gut could be advantageously used as a complement to ex vivo and in vivo studies for the development and testing of new feed additives.

引用

页码：851 / 873

页数：23

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