Complete response after "neoadjuvant" pertuzumab plus trastuzumab plus docetaxel chemotherapy in Her2-positive breast cancer

It is well demonstrated that Her-2 positive breast cancer patients have more aggressive disease, with a poor prognosis. The author report the case of a 50-year-old Caucasian woman, diagnosed with a seven-centimeter right breast cancer. Biospy core revealed a Her-2 positive, positive for hormonal receptors, ki67 at 70%, breast invasive ductal carcinoma, associated with right axillary adenomegalies. Positron emission tomography scan showed diffuse metastatic adenomegalies upper and under the diaphragm and a 55x55 mm lesion in the right breast. The patient began chemotherapy with docetaxel+pertuzumab+trastuzumab regimen. After three courses, all the positron emission tomography scans did not show any pathological hypermetabolism and the primitive lesion was measured at 16x18 mm. It was decided to perform a right mastectomy. The patient will then follow maintenance with pertuzumab and trastuzumab, in combination with hormonotherapy.