A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction

被引：77

作者：

Allin, SM ^{[1
]}

Northfield, CJ

Page, MI

Slawin, AMZ

机构：

[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] Univ Huddersfield, Dept Chem & Biol Sci, Huddersfield HD1 3DH, W Yorkshire, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(98)00892-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4905 / 4908

页数：4

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