Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells

被引:142
作者
Jackson, Joshua M. [1 ,2 ]
Witek, Malgorzata A. [1 ,2 ,3 ]
Kamande, Joyce W. [3 ]
Soper, Steven A. [1 ,2 ,4 ,5 ]
机构
[1] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA
[2] Univ Kansas, Ctr Biomodular Multiscale Syst Precis Med, Lawrence, KS 66045 USA
[3] Univ North Carolina Chapel Hill, Dept Biomed Engn, Chapel Hill, NC USA
[4] Univ Kansas, Dept Mech Engn, Lawrence, KS 66045 USA
[5] BioFluidica Inc, Biosci & Technol Business Ctr, Lawrence, KS 66047 USA
关键词
EPITHELIAL-MESENCHYMAL TRANSITION; ADHESION MOLECULE ANTIBODIES; SELECTIN-MEDIATED CAPTURE; IRON-OXIDE NANOPARTICLES; BREAST-CANCER PATIENTS; PERIPHERAL-BLOOD; LABEL-FREE; HIGHLY EFFICIENT; GENE-EXPRESSION; PROGENITOR CELLS;
D O I
10.1039/c7cs00016b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We present a critical review of microfluidic technologies and material effects on the analyses of circulating tumour cells (CTCs) selected from the peripheral blood of cancer patients. CTCs are a minimally invasive source of clinical information that can be used to prognose patient outcome, monitor minimal residual disease, assess tumour resistance to therapeutic agents, and potentially screen individuals for the early diagnosis of cancer. The performance of CTC isolation technologies depends on microfluidic architectures, the underlying principles of isolation, and the choice of materials. We present a critical review of the fundamental principles used in these technologies and discuss their performance. We also give context to how CTC isolation technologies enable downstream analysis of selected CTCs in terms of detecting genetic mutations and gene expression that could be used to gain information that may affect patient outcome.
引用
收藏
页码:4245 / 4280
页数:36
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