A short synthetic pathway to a fully-functionalized southern hemisphere of the antitumor macrolide bryostatin 1

被引：21

作者：

Hale, KJ ^{[1
]}

Frigerio, M ^{[1
]}

Manaviazar, S ^{[1
]}

机构：

[1] UCL, Dept Chem, Christopher Ingold Labs, London WC1H 0AJ, England

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 23期

关键词：

D O I：

10.1021/ol016800b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] An 18-step asymmetric synthesis of the bryostatin 1 "southern hemisphere" fragment (1) has been developed. Key steps include an aldol reaction between 6 and 7 and a dehydration to establish the (E)-exocyclic alkene in 2 and a stereoselective Luche reduction and protection with TESOTf to access 1.

引用

页码：3791 / 3794

页数：4

共 47 条

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