Oxadiazole isomers: all bioisosteres are not created equal

被引：34

作者：

Goldberg, Kristin ^{[1
]}

Groombridge, Sam ^{[1
]}

Hudson, Julian ^{[1
]}

Leach, Andrew G. ^{[1
]}

MacFaul, Philip A. ^{[1
]}

Pickup, Adrian ^{[1
]}

Poultney, Ruth ^{[1
]}

Scott, James S. ^{[1
]}

Svensson, Per H. ^{[2
,3
]}

Sweeney, Joseph ^{[4
]}

机构：

[1] AstraZeneca, Cardiovasc & Gastrointestinal Innovat Med Unit, Macclesfield SK10 4TG, Cheshire, England

[2] AstraZeneca R&D Sodertalje, Pharm Dev, Med Evaluat CNSP, S-15185 Sodertalje, Sweden

[3] Royal Inst Technol, Sch Chem Sci & Engn, S-10044 Stockholm, Sweden

[4] Univ Huddersfield, Dept Chem, Huddersfield HD1 3DH, W Yorkshire, England

来源：

MEDCHEMCOMM | 2012年 / 3卷 / 05期

关键词：

HYDROLYSIS; PREDICTION; CONSTANTS;

D O I：

10.1039/c2md20054f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

引用

页码：600 / 604

页数：5

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