Dorsolateral prefrontal cortex promotes long-term memory formation through its role in working memory organization

被引:278
|
作者
Blumenfeld, RS
Ranganath, C
机构
[1] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA
来源
JOURNAL OF NEUROSCIENCE | 2006年 / 26卷 / 03期
关键词
prefrontal; encoding; memory; organization; dorsolateral; fMRI;
D O I
10.1523/JNEUROSCI.2353-05.2006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Results from neuroimaging studies have shown that the dorsolateral prefrontal cortex (DLPFC) implements processes critical for organizing items in working memory(WM). Based on its role in WM, we hypothesized that the DLPFC should contribute to long-term memory (LTM) formation by strengthening associations among items that are organized in WM. We conducted an event-related functional magnetic resonance imaging ( fMRI) study to test this hypothesis by investigating prefrontal activity during performance of two different WM tasks: on "rehearse" trials, participants actively maintained triplets of words during a brief delay, whereas on "reorder" trials, participants actively organized each triplet during the delay. After scanning, subjects performed an LTM test on words presented during both WM conditions. Behavioral results showed that WM processing in the reorder condition enhanced LTM by strengthening inter-item associations. fMRI results showed that DLPFC activity specifically during reorder trials was predictive of subsequent LTM. In contrast, activity in the posterior ventrolateral prefrontal cortex was predictive of LTM for words studied on both reorder and rehearse trials. These results support the view that the DLPFC contributes to LTM formation through its role in organization of information in WM.
引用
收藏
页码:916 / 925
页数:10
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