A CuAAC/Ullmann C-C Coupling Tandem Reaction: Copper-Catalyzed Reactions of Organic Azides with N-(2-Iodoaryl)propiolamides or 2-Iodo-N-(prop-2-ynyl)benzenamines

被引：97

作者：

Cai, Qian ^{[1
]}

Yan, Jiajie

Ding, Ke

机构：

[1] Chinese Acad Sci, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 13期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; CLICK CHEMISTRY; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; ARYL HALIDES; N-ARYLATION; 1,3-DIPOLAR CYCLOADDITIONS; MULTICOMPONENT; EFFICIENT; N-(2-HALOARYL)PROPIOLAMIDES; LIGATION;

D O I：

10.1021/ol301307x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel copper-catalyzed tandem reaction was developed by utilizing two famous copper-catalyzed reactions, CuAAC and Ullmann coupling. The trapping of the C-Cu intermediate produced in CuAAC led to further formation of an aryl C-C bond through intramolecular Ullmann C-C coupling.

引用

页码：3332 / 3335

页数：4

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