Identification and validation of SNHG gene signature to predict malignant behaviors and therapeutic responses in glioblastoma

被引:6
作者
Fan, Yang [1 ,2 ,3 ]
Gao, Zijie [1 ,2 ,3 ]
Xu, Jianye [1 ,2 ,3 ]
Wang, Huizhi [1 ,2 ,3 ]
Guo, Qindong [1 ,2 ,3 ]
Xue, Hao [1 ,2 ,3 ]
Zhao, Rongrong [1 ,2 ,3 ]
Guo, Xing [1 ,2 ,3 ]
Li, Gang [1 ,2 ,3 ]
机构
[1] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Neurosurg, Jinan, Peoples R China
[2] Shandong Univ, Inst Brain & Brain Inspired Sci, Jinan, Peoples R China
[3] Shandong Key Lab Brain Funct Remodeling, Jinan, Peoples R China
基金
中国国家自然科学基金;
关键词
glioblastoma; lncRNA; GSC; radiotherapy; immunotherapy; chemotherapy; pan-cancer; CENTRAL-NERVOUS-SYSTEM; CANCER STEM-CELL; MESENCHYMAL DIFFERENTIATION; HOST GENES; CLASSIFICATION; PROGRESSION; DISCOVERY; ORIGIN; TUMORS;
D O I
10.3389/fimmu.2022.986615
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Glioblastoma (GBM) patients exhibit high mortality and recurrence rates despite multimodal therapy. Small nucleolar RNA host genes (SNHGs) are a group of long noncoding RNAs that perform a wide range of biological functions. We aimed to reveal the role of SNHGs in GBM subtypes, cell infiltration into the tumor microenvironment (TME), and stemness characteristics. SNHG interaction patterns were determined based on 25 SNHGs and systematically correlated with GBM subtypes, TME and stemness characteristics. The SNHG interaction score (SNHGscore) model was generated to quantify SNHG interaction patterns. The high SNHGscore group was characterized by a poor prognosis, the mesenchymal (MES) subtype, the infiltration of suppressive immune cells and a differentiated phenotype. Further analysis indicated that high SNHGscore was associated with a weaker response to anti-PD-1/L1 immunotherapy. Tumor cells with high SNHG scores were more sensitive to drugs targeting the EGFR and ERK-MAPK signaling pathways. Finally, we assessed SNHG interaction patterns in multiple cancers to verify their universality. This is a novel and comprehensive study that provides targeted therapeutic strategies based on SNHG interactions. Our work highlights the crosstalk and potential clinical utility of SNHG interactions in cancer therapy.
引用
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页数:16
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