The study on the preparation and spectroscopic properties of hydroxypropyl-β-cyclodextrin/glipizide inclusion complex

被引：0
|
作者：
Zhang Yi-min [1 ]
Li Xiao [1 ]
Sun Cong-shan [1 ]
Chen Chun-feng [1 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, Minist Educ, Key Lab Green Chem Technol, Tianjin 300072, Peoples R China
来源：
SPECTROSCOPY AND SPECTRAL ANALYSIS | 2008年 / 28卷 / 03期
关键词：
glipizide; hydroxypropyl-beta-cyclodextrin; inclusion complex; IR; XRD;
D O I：
暂无
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
The interaction of glipizide and hydroxypropyl-beta-cyclodextrin was investigated in the present paper. The stability constant and molar ratio of glipizide and hydroxypropyl-beta-cyclodextrin was calculated from the phase soluility diagram. The solid state inclusion complex of hydroxypropyl-beta-cyclodextrin/glipizide prepared by neutralization method was characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD). It was found that the phase solubility diagram of the HP-beta-CD solution showed a typical AL-type, suggesting the formation of a soluble complex of 1 : 1 molar ratio, and the stability constant was 359 L . mol(-1) at 25 degrees C. The spectra of IR, thermograph of DSC and XRD pattern of the inclusion complex were remarkably different from the glipizide and hydroxypropyl-beta-cyclodextrin/glipizide physical mixture, and indicated that hydroxypropyl-beta-cyclodextrin/glipizide inclusion complex displayed amorphous characteristic. The experiment of solubility of inclusion complex indicated that the solubility of inclusion complex increased 25-fold.
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页码：711 / 714
页数：4
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