Wound healing activity of flaxseed Linum usitatissimum L. in rats

Wound healing is a complex process which requires special factors and condition. Drugs which accelerate wound healing are expanded, particularly herbal drugs which are mainly safe and effective. Hence, the present study was conducted to evaluate wound healing activity of flaxseed oil on experimentally induced incision wound. The therapeutic ointments were prepared according to two concentrations, 0.75 and 1.5%, and were applied to wound. 32 male rats were divided into 4 groups of 8 rats. Two circle-shapes, full thickness wounds with 7 mm(2) in diameters were made in both side of backbone. Tissue samples were obtained at the end of 3, 7, 14 and 21 days from all groups and were stained with hematoxylin and eosin, then were reviewed under light microscope. Treated animals showed significant reduction of inflammatory cells in the period of re-epithelization. Flaxseed oil significantly accelerates wound healing process and suggested flaxseed as an effective herbal drug for wound in skin.