A Versatile Synthesis of Substituted Isoquinolines

被引：45

作者：

Si, Chong ^{[1
]}

Myers, Andrew G. ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 44期

关键词：

cyclization; nitriles; nitrogen heterocycles; o-tolualdehyde tert-butylimines; synthetic methods; SPONGE CORTICIUM-SIMPLEX; PALLADIUM-CATALYZED IMINOANNULATION; MEDIATED ELECTROPHILIC CYCLIZATION; STEROIDAL ALKALOIDS; PROTEIN-KINASE; DIRECTED METALATION; ALKYNES; PYRIDINES; 2-(1-ALKYNYL)BENZALDIMINES; HYDROXYLATION;

D O I：

10.1002/anie.201104769

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lithiated o-tolualdehyde tert-butylimines were shown to condense with nitriles to form eneamido anion intermediates that were trapped in situ with various electrophiles, thus affording a diverse array of highly substituted isoquinolines, many of which are difficult to access by known methods. Further substitutional diversification was achieved by modification of the work-up conditions and by subsequent transformations. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：10409 / 10413

页数：5

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